New strategies against an old plague: genetically engineered tuberculosis vaccines.

Details

Serval ID
serval:BIB_3E9095647AAF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
New strategies against an old plague: genetically engineered tuberculosis vaccines.
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Dreher D., Kok M., Pechère J.C., Nicod L.P.
ISSN
0036-7672[print], 0036-7672[linking]
Publication state
Published
Issued date
2000
Volume
130
Number
50
Pages
1925-1929
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
The failure of BCG vaccination to control the global tuberculosis epidemic and the spread of multidrug resistance underline the need for a better vaccine. Recent advances in molecular microbiology, gene therapy, and, last but not least, immunobiology, provide a rational basis for the development of more efficient vaccines against tuberculosis. The complete sequencing of the M. tuberculosis genome marked a turning point in tuberculosis vaccine research. The advent of genetic vaccination with either naked DNA, live recombinant, or artificial vaccine vectors holds out great promise of more efficient immunisation, in particular against intracellular pathogens such as M. tuberculosis. Our new understanding of how the immune response is orchestrated by dendritic cells makes it possible to design vaccines which specifically exploit the functions of these antigen presenting cells. Yet M. tuberculosis has kept many of its secrets, and although functional genomics, molecular medicine and immunotherapy are evolving rapidly, much empiric search and discovery are needed until the "captain of all these men of death" gives up his ghost to biotechnology.
Keywords
BCG Vaccine, Genetic Engineering, Humans, Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/immunology, Tuberculosis/immunology, Tuberculosis/prevention & control, Vaccines, Synthetic
Pubmed
Web of science
Create date
19/02/2010 18:58
Last modification date
20/08/2019 13:35
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