Patterns of cerebral blood flow in schizophrenia.
Details
Serval ID
serval:BIB_3E8F6B609843
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patterns of cerebral blood flow in schizophrenia.
Journal
British Journal of Psychiatry
ISSN
0007-1250 (Print)
ISSN-L
0007-1250
Publication state
Published
Issued date
1992
Volume
160
Pages
179-186
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Positron emission tomography was used to study the relationship between rCBF and symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms segregated into three syndromes--psychomotor poverty, disorganisation, and reality distortion--described previously. Analysis of the correlations between syndrome scores and rCBF revealed that each syndrome was associated with a specific pattern of perfusion in paralimbic and association cortex, and in related subcortical nuclei. The study confirmed predictions that psychomotor poverty and disorganisation are associated with altered perfusion at different loci in the pre-frontal cortex, and reality distortion with altered perfusion in the medial temporal lobe. The perfusion patterns suggest that the abnormalities of brain function underlying each of the three syndromes are not confined to single loci, but involve distributed neuronal networks.
Keywords
Adult, Brain/physiopathology, Cerebrovascular Circulation, Female, Humans, Male, Psychiatric Status Rating Scales, Schizophrenia/classification, Schizophrenia/diagnosis, Temporal Lobe/blood supply, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 16:33
Last modification date
20/08/2019 13:35