DHEA therapy in postmenopausal women: the need to move forward beyond the lack of evidence.

Details

Serval ID
serval:BIB_3E86FED3E8A9
Type
Article: article from journal or magazin.
Collection
Publications
Title
DHEA therapy in postmenopausal women: the need to move forward beyond the lack of evidence.
Journal
Climacteric
Author(s)
Genazzani A.R., Pluchino N.
ISSN
1473-0804 (Electronic)
ISSN-L
1369-7137
Publication state
Published
Issued date
08/2010
Peer-reviewed
Oui
Volume
13
Number
4
Pages
314-316
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The marked age-related decline in serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) has suggested that a deficiency of these steroids may be causally related to the development of a series of diseases that are generally associated with aging. Postulated consequences of low DHEA levels include insulin resistance, obesity, cardiovascular disease, cancer, reduction of the immune defence system as well as psychosocial problems such as depression and a general deterioration in the sensation of well-being and cognitive function. Clinically, the spectrum of women that would benefit from DHEA therapy is not clearly defined and nor is the dosage of hormone treatment. Whether DHEA therapy could be prescribed as a general anti-aging therapy or could be an alternative treatment for women suffering from androgen deficiency syndrome remains uncertain across studies. The lack of definitive evidence for biological mechanisms and the presence of only a few studies that address these emerging issues of DHEA therapy in postmenopausal women might encourage a new critical analysis of the available literature, evidencing current limits and incongruities.
Keywords
Aging/physiology, Dehydroepiandrosterone/deficiency, Dehydroepiandrosterone/physiology, Dehydroepiandrosterone/therapeutic use, Dehydroepiandrosterone Sulfate/blood, Female, Hormone Replacement Therapy/methods, Humans, Postmenopause/blood, Sexual Behavior/physiology
Pubmed
Web of science
Create date
15/09/2023 12:24
Last modification date
27/09/2023 8:23
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