LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite.

Details

Serval ID
serval:BIB_3E762A2EBC0C
Type
Article: article from journal or magazin.
Collection
Publications
Title
LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite.
Journal
Nature
Author(s)
Toni N., Buchs P.A., Nikonenko I., Bron C.R., Muller D.
ISSN
0028-0836
Publication state
Published
Issued date
11/1999
Peer-reviewed
Oui
Volume
402
Number
6760
Pages
421-425
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Structural remodelling of synapses and formation of new synaptic contacts has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory. Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines. LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines. Three-dimensional reconstruction revealed that these spines arose from the same dendrite. As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapses.
Keywords
Axons/physiology, Axons/ultrastructure, Calcium/metabolism, Dendrites/physiology, Dendrites/ultrastructure, Hippocampus/physiology, Hippocampus/ultrastructure, Long-Term Potentiation/physiology, Organ Culture Techniques, Synapses/physiology, Synapses/ultrastructure, Time Factors
Pubmed
Web of science
Create date
22/01/2010 8:07
Last modification date
20/08/2019 13:35
Usage data