Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Details

Serval ID
serval:BIB_3E711CEC2DDF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.
Journal
Molecular Pharmaceutics
Author(s)
Smith D., Artursson P., Avdeef A., Di L., Ecker G.F., Faller B., Houston J.B., Kansy M., Kerns E.H., Krämer S.D., Lennernäs H., van de Waterbeemd H., Sugano K., Testa B.
ISSN
1543-8392 (Electronic)
ISSN-L
1543-8384
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
11
Number
6
Pages
1727-1738
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish Document Type: Review, pdf : Review
Abstract
Recently, it has been proposed that drug permeation is essentially carrier-mediated only and that passive lipoidal diffusion is negligible. This opposes the prevailing hypothesis of drug permeation through biological membranes, which integrates the contribution of multiple permeation mechanisms, including both carrier-mediated and passive lipoidal diffusion, depending on the compound's properties, membrane properties, and solution properties. The prevailing hypothesis of drug permeation continues to be successful for application and prediction in drug development. Proponents of the carrier-mediated only concept argue against passive lipoidal diffusion. However, the arguments are not supported by broad pharmaceutics literature. The carrier-mediated only concept lacks substantial supporting evidence and successful applications in drug development.
Pubmed
Web of science
Create date
04/07/2014 16:40
Last modification date
20/08/2019 13:35
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