Therapeutic microRNA strategies in human cancer.

Details

Serval ID
serval:BIB_3E3C6E8EF57F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Therapeutic microRNA strategies in human cancer.
Journal
AAPS Journal
Author(s)
Li C., Feng Y., Coukos G., Zhang L.
ISSN
1550-7416 (Electronic)
ISSN-L
1550-7416
Publication state
Published
Issued date
2009
Volume
11
Number
4
Pages
747-757
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; ReviewPublication Status: ppublish
Abstract
MicroRNAs (miRNAs) are approximately 22 nucleotide long, noncoding, endogenous RNA molecules which exert their functions by base pairing with messenger RNAs (mRNAs), thereby regulate protein-coding gene expression. In eukaryotic cells, miRNAs play important roles in regulating biological processes such as proliferation, differentiation, apoptosis, and stem cell self-renewal. The human genome may contain as many as 1,000 miRNAs, and more than 700 of them have been identified. miRNAs are predicted to target up to one third of mRNAs. Each miRNA can target hundreds of transcripts directly or indirectly, while more than one miRNA can converge on a single transcript target. Therefore, the potential regulatory circuitry afforded by miRNA is enormous. Recently, mounting evidence implicates miRNAs as a new class of modulator for human tumor initiation and progression. Therefore, it has been proposed that manipulating miRNA activity and miRNA biogenesis may be a novel avenue for developing efficient therapies against cancer.
Keywords
Gene Expression Regulation, Neoplastic/genetics, Gene Silencing, Gene Targeting, Genes, Tumor Suppressor/physiology, Genetic Therapy/methods, Humans, MicroRNAs/administration & dosage, MicroRNAs/biosynthesis, Neoplasms/genetics, Neoplasms/therapy, Neoplastic Stem Cells, Oncogenes/genetics, RNA, Small Interfering/administration & dosage, RNA, Small Interfering/therapeutic use
Pubmed
Create date
14/10/2014 11:43
Last modification date
20/08/2019 13:34
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