Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.

Details

Serval ID
serval:BIB_3E2721FF75A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.
Journal
Brain structure & function
Author(s)
Chareyron L.J., Banta Lavenex P., Amaral D.G., Lavenex P.
ISSN
1863-2661 (Electronic)
ISSN-L
1863-2653
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
222
Number
9
Pages
3899-3914
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Hippocampal damage in adult humans impairs episodic and semantic memory, whereas hippocampal damage early in life impairs episodic memory but leaves semantic learning relatively preserved. We have previously shown a similar behavioral dissociation in nonhuman primates. Hippocampal lesion in adult monkeys prevents allocentric spatial relational learning, whereas spatial learning persists following neonatal lesion. Here, we quantified the number of cells expressing the immediate-early gene c-fos, a marker of neuronal activity, to characterize the functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion. Ninety minutes before brain collection, three control and four adult monkeys with bilateral neonatal hippocampal lesions explored a novel environment to activate brain structures involved in spatial learning. Three other adult monkeys with neonatal hippocampal lesions remained in their housing quarters. In unlesioned monkeys, we found high levels of c-fos expression in the intermediate and caudal regions of the entorhinal cortex, and in the perirhinal, parahippocampal, and retrosplenial cortices. In lesioned monkeys, spatial exploration induced an increase in c-fos expression in the intermediate field of the entorhinal cortex, the perirhinal, parahippocampal, and retrosplenial cortices, but not in the caudal entorhinal cortex. These findings suggest that different regions of the medial temporal lobe memory system may require different types of interaction with the hippocampus in support of memory. The caudal perirhinal cortex, the parahippocampal cortex, and the retrosplenial cortex may contribute to spatial learning in the absence of functional hippocampal circuits, whereas the caudal entorhinal cortex may require hippocampal output to support spatial learning.
Keywords
Analysis of Variance, Animals, Animals, Newborn, Brain Mapping, Cell Count, Exploratory Behavior/physiology, Female, Gene Expression/drug effects, Gene Expression/physiology, Hippocampus/injuries, Hippocampus/pathology, Macaca mulatta, Male, Memory/physiology, Neural Pathways/physiology, Proto-Oncogene Proteins c-fos/metabolism, Temporal Lobe/physiology, Cingulate, Entorhinal, Hippocampus, Parahippocampal, Perirhinal, Retrosplenial
Pubmed
Web of science
Create date
12/05/2017 14:46
Last modification date
20/08/2019 13:34
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