Back to the Cradle of Cytotherapy: Integrating a Century of Clinical Research and Biotechnology-Based Manufacturing for Modern Tissue-Specific Cellular Treatments in Switzerland.

Details

Serval ID
serval:BIB_3E261CA71905
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Back to the Cradle of Cytotherapy: Integrating a Century of Clinical Research and Biotechnology-Based Manufacturing for Modern Tissue-Specific Cellular Treatments in Switzerland.
Journal
Bioengineering
Author(s)
Laurent A., Abdel-Sayed P., Scaletta C., Laurent P., Laurent E., Michetti M., de Buys Roessingh A., Raffoul W., Hirt-Burri N., Applegate L.A.
ISSN
2306-5354 (Print)
ISSN-L
2306-5354
Publication state
Published
Issued date
17/12/2021
Peer-reviewed
Oui
Volume
8
Number
12
Pages
221
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Empirically studied by Dr. Brown-Séquard in the late 1800s, cytotherapies were later democratized by Dr. Niehans during the twentieth century in Western Switzerland. Many local cultural landmarks around the Léman Riviera are reminiscent of the inception of such cell-based treatments. Despite the discreet extravagance of the remaining heirs of "living cell therapy" and specific enforcements by Swiss health authorities, current interest in modern and scientifically sound cell-based regenerative medicine has never been stronger. Respective progress made in bioengineering and in biotechnology have enabled the clinical implementation of modern cell-based therapeutic treatments within updated medical and regulatory frameworks. Notably, the Swiss progenitor cell transplantation program has enabled the gathering of two decades of clinical experience in Lausanne for the therapeutic management of cutaneous and musculoskeletal affections, using homologous allogeneic cell-based approaches. While striking conceptual similarities exist between the respective works of the fathers of cytotherapy and of modern highly specialized clinicians, major and important iterative updates have been implemented, centered on product quality and risk-analysis-based patient safety insurance. This perspective article highlights some historical similarities and major evolutive differences, particularly regarding product safety and quality issues, characterizing the use of cell-based therapies in Switzerland over the past century. We outline the vast therapeutic potential to be harnessed for the benefit of overall patient health and the importance of specific scientific methodological aspects.
Keywords
biotechnological manufacturing, cell banking, cell therapy, cellular extracts, living cell therapy, primary progenitor cells, quality requirements, regenerative medicine, therapeutic products, transplantation program
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2022 10:09
Last modification date
15/01/2022 7:32
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