Myocardial extracellular volume by T1 mapping: a new marker of arrhythmia in mitral valve prolapse.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_3E02B9ACCB6E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Myocardial extracellular volume by T1 mapping: a new marker of arrhythmia in mitral valve prolapse.
Journal
Journal of cardiovascular magnetic resonance
Author(s)
Pavon A.G., Arangalage D., Pascale P., Hugelshofer S., Rutz T., Porretta A.P., Le Bloa M., Muller O., Pruvot E., Schwitter J., Monney P.
ISSN
1532-429X (Electronic)
ISSN-L
1097-6647
Publication state
Published
Issued date
13/09/2021
Peer-reviewed
Oui
Volume
23
Number
1
Pages
102
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
We aimed to evaluate the relationship between mitral annular disjunction (MAD) severity and myocardial interstitial fibrosis at the left ventricular (LV) base in patients with mitral valve prolapse (MVP), and to assess the association between severity of interstitial fibrosis and the occurrence of ventricular arrhythmic events.
In MVP, MAD has been associated with myocardial replacement fibrosis and arrhythmia, but the importance of interstitial fibrosis remains unknown.
In this retrospective study, 30 patients with MVP and MAD (MVP-MAD) underwent cardiovascular magnetic resonance (CMR) with assessment of MAD length, late gadolinium enhancement (LGE), and basal segments myocardial extracellular volume (ECVsyn). The control group included 14 patients with mitral regurgitation (MR) but no MAD (MR-NoMAD) and 10 patients with normal CMR (NoMR-NoMAD). Fifteen MVP-MAD patients underwent 24 h-Holter monitoring.
LGE was observed in 47% of MVP-MAD patients and was absent in all controls. ECVsyn was higher in MVP-MAD (30 ± 3% vs 24 ± 3% MR-NoMAD, p < 0.001 and vs 24 ± 2% NoMR-NoMAD, p < 0.001), even in MVP-MAD patients without LGE (29 ± 3% vs 24 ± 3%, p < 0.001 and vs 24 ± 2%, p < 0.001, respectively). MAD length correlated with ECVsyn (rho = 0.61, p < 0.001), but not with LGE extent. Four patients had history of out-of-hospital cardiac arrest; LGE and ECVsyn were equally performant to identify those high-risk patients, area under the receiver operating characteristic (ROC) curve 0.81 vs 0.83, p = 0.84). Among patients with Holter, 87% had complex ventricular arrhythmia. ECVsyn was above the cut-off value in all while only 53% had LGE.
Increase in ECVsyn, a marker of interstitial fibrosis, occurs in MVP-MAD even in the absence of LGE, and was correlated with MAD length and increased risk of out-of-hospital cardiac arrest. ECV should be includedin the CMR examination of MVP patients in an effort to better assess fibrous remodelling as it may provide additional value beyond the assessment of LGE in the arrhythmic risk stratification.
Keywords
Cardiology and Cardiovascular Medicine, Radiology Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Cardiovascular magnetic resonance, Interstitial fibrosis, Mitral annular disjunction, Mitral valve prolapse
Pubmed
Web of science
Open Access
Yes
Create date
14/09/2021 23:47
Last modification date
02/10/2021 6:36
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