Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment.

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Version: Author's accepted manuscript
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State: Public
Version: Supplementary document
Serval ID
serval:BIB_3DE3D0341247
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Importance of early weight changes to predict long-term weight gain during psychotropic drug treatment.
Journal
Journal of Clinical Psychiatry
Author(s)
Vandenberghe F., Gholam-Rezaee M., Saigí-Morgui N., Delacrétaz A., Choong E., Solida-Tozzi A., Kolly S., Thonney J., Gallo S.F., Hedjal A., Ambresin A.E., von Gunten A., Conus P., Eap C.B.
ISSN
1555-2101 (Electronic)
ISSN-L
0160-6689
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
76
Number
11
Pages
e1417-e1423
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: Psychotropic drugs can induce substantial weight gain, particularly during the first 6 months of treatment. The authors aimed to determine the potential predictive power of an early weight gain after the introduction of weight gain-inducing psychotropic drugs on long-term weight gain.
METHOD: Data were obtained from a 1-year longitudinal study ongoing since 2007 including 351 psychiatric (ICD-10) patients, with metabolic parameters monitored (baseline and/or 1, 3, 6, 9, 12 months) and with compliance ascertained. International Diabetes Federation and World Health Organization definitions were used to define metabolic syndrome and obesity, respectively.
RESULTS: Prevalences of metabolic syndrome and obesity were 22% and 17%, respectively, at baseline and 32% and 24% after 1 year. Receiver operating characteristic analyses indicated that an early weight gain > 5% after a period of 1 month is the best predictor for important long-term weight gain (≥ 15% after 3 months: sensitivity, 67%; specificity, 88%; ≥ 20% after 12 months: sensitivity, 47%; specificity, 89%). This analysis identified most patients (97% for 3 months, 93% for 12 months) who had weight gain ≤ 5% after 1 month as continuing to have a moderate weight gain after 3 and 12 months. Its predictive power was confirmed by fitting a longitudinal multivariate model (difference between groups in 1 year of 6.4% weight increase as compared to baseline, P = .0001).
CONCLUSION: Following prescription of weight gain-inducing psychotropic drugs, a 5% threshold for weight gain after 1 month should raise clinician concerns about weight-controlling strategies.
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2015 10:24
Last modification date
20/08/2019 14:34
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