Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes.

Details

Serval ID
serval:BIB_3DE1FA5DB11C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Proximal tibial osteophyte volumes are correlated spatially and with knee alignment: a quantitative analysis suggesting the influence of biochemical and mechanical factors in the development of osteophytes.
Journal
Osteoarthritis and cartilage
Author(s)
Omoumi P., Schuler A., Babel H., Stoffel C., Jolles B.M., Favre J.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Publication state
Published
Issued date
12/2021
Peer-reviewed
Oui
Volume
29
Number
12
Pages
1691-1700
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle.
CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compartments. Non-parametric statistics was used for comparison and correlation analyses.
Total osteophyte volumes were larger in the medial than in the lateral compartment for all severity groups (p < 0.05). Additionally, statistically significant differences were observed among subregions of the lateral compartment in K/L3 and K/L4 knees. Statistically significant positive correlations were found between the medial and lateral total osteophyte volumes in K/L3 and K/L4 knees (ρ ≥ 0.44, p = 0.03), and among most subregional osteophyte volumes within each compartment in K/L3 knees. Markedly fewer statistically significant correlations were present in K/L2 and K/L4 knees. In K/L3 knees, the femorotibial angle was statistically significantly positively correlated with the total osteophyte volume in the medial compartment (ρ = 0.50, p = 0.01), with osteophyte volumes in most medial subregions, and with the osteophyte volume in the lateral posterior subregion (ρ = 0.40, p = 0.05).
Quantitative assessment of osteophytes may bring insight on factors influencing their development. Positive correlations of osteophyte volumes found between and within compartments suggest the influence of biochemical mediators acting on the entire joint, while positive correlations between the femorotibial angle and osteophyte volumes suggest a role of mechanical factors. These hypotheses are to be further confirmed.
Keywords
Osteoarthritis, X-ray Computed Tomography, knee, osteophyte, segmentation, topography, Knee, Osteophyte, Segmentation, Topography, X-ray computed tomography
Pubmed
Web of science
Open Access
Yes
Create date
04/10/2021 11:28
Last modification date
08/03/2022 7:34
Usage data