Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status

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Serval ID
serval:BIB_3DB3397963DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status
Journal
Rheumatology
Author(s)
So  A., Chamot  A. M., Peclat  V., Gerster  J. C.
ISSN
1462-0324 (Print)
Publication state
Published
Issued date
05/1999
Volume
38
Number
5
Pages
407-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
OBJECTIVE: Metalloproteinases (MMP) play an important role in the remodelling of the extracellular matrix. However, evidence that they are responsible for tissue damage in pathological situations remains circumstantial. Stromelysin (MMP-3) production is increased in rheumatoid arthritis (RA), and has been proposed as a marker of joint damage. The relevance of serum levels of MMP-3 to erosions in RA was studied. METHODS: Fifty-three patients with active RA of > 5 yr duration and with available X-rays were stratified according to disease duration. Hand X-rays were scored for erosions. Patients were then classified into upper and lower quartiles. Serum MMP-3 levels were compared between these two groups. RESULTS: No significant differences in serum MMP-3 were seen between high and low eroders. A statistically significant correlation was observed between sMMP-3 and erthyrocyte sedimentation rate and C-reactive protein. CONCLUSIONS: Serum MMP-3 is not an independent marker of joint damage, but is correlated with systemic inflammation. Its precise role in joint damage in RA remains to be elucidated.
Keywords
Adult *Arthritis, Rheumatoid/enzymology/immunology/pathology Biological Markers C-Reactive Protein/metabolism Cohort Studies Cross-Sectional Studies Extracellular Matrix/immunology Female Humans Inflammation/immunology Joints/enzymology/immunology/pathology Male Matrix Metalloproteinase 3/*blood Middle Aged
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:39
Last modification date
25/09/2019 7:09
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