Cerveau et régénérescence

Details

Serval ID
serval:BIB_3D8DD1B0A714
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Cerveau et régénérescence
Title of the conference
Symposium Vie et mort des neurones, semaine du cerveau
Author(s)
Arsenijevic Y.
Address
Lausanne
ISBN
1661-3686
Publication state
Published
Issued date
2003
Series
Schweizer Archiv für Neurologie und Psychiatrie
Language
french
Notes
Contrary to the dogma taught in decades which inferred that the brain contains at birth all the cells necessary for its organisation, it is now well established that certain regions of the brain generate new neurons in adulthood. In rodents and monkeys, the olfactory bulb, the hippocampus and the associative cortex form neurons throughout life. The generation of new neurons is dependent on environmental factors such as stress, learning and exercise. In rodents neurogenesis can also occur after a lesion: focal lesions in the cortex stimulate the formation of new neurons able to connect to the right target showing the capacity of the brain to regenerate in certain situations. Neurogenesis was also revealed in the adult human hippocampus suggesting that the discoveries based on monkey studies could be transposed to the human brain. Neurogenic regions contain cells able to proliferate in vitro and to generate neurons and glia. This approach allows to study human neurogenesis in the laboratory in order to understand molecular mechanisms that control neuron survival and differentiation and to potentially produce neurons for cell transplantation studies. It appears that our brain maintains, throughout life, the capacity to generate new neurons in various brain areas, probably as a way of better adapting to environment fluctuations. This characteristic opens new perspectives for therapeutical approaches.
Keywords
neurogenesis, stem cells, glia, human
Create date
28/01/2008 12:31
Last modification date
20/08/2019 13:33
Usage data