Molecular approaches towards the isolation of sleep-related genes.

Details

Serval ID
serval:BIB_3D5D0E44CE8F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Molecular approaches towards the isolation of sleep-related genes.
Journal
Journal of Sleep Research
Author(s)
Schibler U., Tafti M.
ISSN
0962-1105[print], 0962-1105[linking]
Publication state
Published
Issued date
06/1999
Volume
8 Suppl 1
Pages
1-10
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Behavioural genetics is one of the most enticing fields in modern biology. Owing to straightforward and semiautomated techniques that can be used to measure locomotor activity, circadian rhythmicity is perhaps the best studied behaviour in animals. Thus, during the past decade, five essential circadian clock genes have been isolated in Drosophila, and homologous counterparts for all of these genes have also been found in mammals. As the sleep-wake cycle is under the control of the circadian clock, these circadian master genes are expected to influence sleeping behaviour. However, different vigilance states are regulated by additional mechanisms that also have a genetic basis. In this article we discuss molecular approaches that may prove useful in the search for sleep-related genes.
Keywords
Animals, Circadian Rhythm/genetics, DNA Primers/genetics, DNA, Complementary/genetics, Drosophila/genetics, Gene Expression/genetics, Gene Library, Genes/genetics, Heterozygote, Linkage (Genetics)/genetics, Mammals/genetics, Molecular Biology, Phenotype, Point Mutation/genetics, Polymerase Chain Reaction, Polymorphism, Genetic/genetics, RNA, Messenger/genetics, Sleep, REM/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:55
Last modification date
20/08/2019 13:33
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