Use of newer antiepileptic drugs and prognosis in adults with status epilepticus: Comparison between 2009 and 2017.
Details
Serval ID
serval:BIB_3D13DCA45B77
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Use of newer antiepileptic drugs and prognosis in adults with status epilepticus: Comparison between 2009 and 2017.
Journal
Epilepsia
ISSN
1528-1167 (Electronic)
ISSN-L
0013-9580
Publication state
Published
Issued date
07/2018
Peer-reviewed
Oui
Volume
59
Number
7
Pages
e98-e102
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time points (the years 2009 and 2017), exploring factors potentially associated with outcome, with particular attention to use of newer antiepileptic drugs (AEDs). Newer AEDs were more often prescribed in SE episodes in 2017 (80.2% vs 38.5%, P < .001); this independently correlated with year of observation, SE refractoriness, nonconvulsive SE forms, and number of AEDs. We observed a higher proportion of deterioration from baseline conditions in 2017 (67.7% vs 42.3%, P < .001), which was independently associated with, among other variables, use of newer AEDs (odds ratio = 2.91, 95% confidence interval = 1.13-7.48), whereas mortality seemed more stable over time (16.1% vs 6.3%, P = .08) without any relationship with newer AEDs. These observations suggest that newer AEDs might affect functional status but not mortality. Further investigations are necessary to improve therapeutic strategies, which currently rely on weak evidence.
Keywords
Activities of Daily Living/classification, Adult, Aged, Anticonvulsants/adverse effects, Anticonvulsants/therapeutic use, Cohort Studies, Correlation of Data, Electroencephalography/drug effects, Female, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Registries, Retrospective Studies, Status Epilepticus/classification, Status Epilepticus/diagnosis, Status Epilepticus/drug therapy, Status Epilepticus/mortality, Survival Rate, Treatment Outcome, anticonvulsant, functional outcome, mortality, treatment
Pubmed
Web of science
Create date
15/06/2018 18:19
Last modification date
20/08/2019 14:33