Hereditary thrombophilia and venous thromboembolism: critical evaluation of the clinical implications of screening

Details

Serval ID
serval:BIB_3CC34FD5C6E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hereditary thrombophilia and venous thromboembolism: critical evaluation of the clinical implications of screening
Journal
European Journal of Vascular and Endovascular Surgery
Author(s)
Mazzolai  L., Duchosal  M. A.
ISSN
1078-5884 (Print)
Publication state
Published
Issued date
10/2007
Volume
34
Number
4
Pages
483-488
Language
english
Notes
Journal Article Review --- Old month value: Oct
Abstract
Venous thromboembolism is a complex disease resulting from the interactions of several risk factors from diverse origins: genetic, environmental and behavioral. Numerous studies have evidenced an association between genetic thrombophilia defects and venous thromboembolism. However, the clinical relevance of genetic thrombophilia to recurrent venous thromboembolism is not clear and the risks of long-term anticoagulant treatment usually outweigh any benefits of hereditary thrombophilia screening. Therefore, in everyday clinical practice (outside of research protocols) hereditary thrombophilia screening should be performed only in cases where such testing is likely to influence patient management.
Keywords
Anticoagulants/therapeutic use Genetic Predisposition to Disease *Genetic Screening Humans Recurrence Risk Assessment Thromboembolism/*etiology/prevention & control Thrombophilia/*genetics Venous Thrombosis/*etiology/prevention & control
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:24
Last modification date
20/08/2019 14:32
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