Biomechanics can be defined as the physical concepts exploring the effects of mechanical forces in biology. Biomechanics explores the consequences of an alteration in the steady-state normally existing between living tissues and their immediate environment. The application of this science in the field of brain physiopathology and intracranial hypertension is essential to understanding the sequence of events triggered during an alteration of the intracranial volume such as observed with intracranial pathologies. Furthermore, biomechanics allows the development of a logical and rational therapeutic approach, better adapted to the various intracerebral problems anaesthesiologists might be confronted with.