Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria.

Details

Serval ID
serval:BIB_3C49A774B392
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria.
Journal
The Journal of experimental medicine
Author(s)
An H., Qian C., Huang Y., Li J., Tian X., Feng J., Hu J., Fang Y., Jiao F., Zeng Y., Huang X., Meng X., Liu X., Lin X., Zeng Z., Guilliams M., Beschin A., Chen Y., Wu Y., Wang J., Oggioni M.R., Leong J., Veening J.W., Deng H., Zhang R., Wang H., Wu J., Cui Y., Zhang J.R.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
04/04/2022
Peer-reviewed
Oui
Volume
219
Number
4
Pages
e20212032
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains largely unknown how the capsules enhance bacterial virulence under in vivo infection conditions. Here we show that the capsules primarily target the liver to enhance bacterial survival at the onset of blood-borne infections. In a mouse sepsis model, the capsules enabled human pathogens Streptococcus pneumoniae and Escherichia coli to circumvent the recognition of liver-resident macrophage Kupffer cells (KCs) in a capsular serotype-dependent manner. In contrast to effective capture of acapsular bacteria by KCs, the encapsulated bacteria are partially (low-virulence types) or completely (high-virulence types) "untouchable" for KCs. We finally identified the asialoglycoprotein receptor (ASGR) as the first known capsule receptor on KCs to recognize the low-virulence serotype-7F and -14 pneumococcal capsules. Our data identify the molecular interplay between the capsules and KCs as a master controller of the fate and virulence of encapsulated bacteria, and suggest that the interplay is targetable for therapeutic control of septic infections.
Pubmed
Create date
14/03/2022 9:29
Last modification date
22/03/2022 7:35
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