Network connectivity determines cortical thinning in early Parkinson's disease progression.

Details

Serval ID
serval:BIB_3C3ADA476E67
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Network connectivity determines cortical thinning in early Parkinson's disease progression.
Journal
Nature communications
Author(s)
Yau Y., Zeighami Y., Baker T.E., Larcher K., Vainik U., Dadar M., Fonov V.S., Hagmann P., Griffa A., Mišić B., Collins D.L., Dagher A.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
02/01/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
12
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Here we test the hypothesis that the neurodegenerative process in Parkinson's disease (PD) moves stereotypically along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls (n = 57) underwent T1-MRI at entry and 1 year later as part of the Parkinson's Progression Markers Initiative. Over this period, PD patients demonstrate significantly greater cortical thinning than controls in parts of the left occipital and bilateral frontal lobes and right somatomotor-sensory cortex. Cortical thinning is correlated to connectivity (measured functionally or structurally) to a "disease reservoir" evaluated by MRI at baseline. The atrophy pattern in the ventral frontal lobes resembles one described in certain cases of Alzheimer's disease. Our findings suggest that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cortex may herald the onset of cognitive impairment.

Keywords
Aged, Case-Control Studies, Cerebral Cortex/pathology, Cognition, Connectome, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease/cerebrospinal fluid, Parkinson Disease/etiology, Parkinson Disease/pathology, Parkinson Disease/psychology
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2018 14:50
Last modification date
20/08/2019 13:32
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