Inosine reduces inflammation and improves survival in a murine model of colitis.

Details

Serval ID
serval:BIB_3C2EB3C3436E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inosine reduces inflammation and improves survival in a murine model of colitis.
Journal
American Journal of Physiology. Gastrointestinal and Liver Physiology
Author(s)
Mabley J.G., Pacher P., Liaudet L., Soriano F.G., Haskó G., Marton A., Szabo C., Salzman A.L.
ISSN
0193-1857
Publication state
Published
Issued date
01/2003
Peer-reviewed
Oui
Volume
284
Number
1
Pages
G138-144
Language
english
Notes
Publication types: Journal Article
Abstract
Inosine, a naturally occurring purine formed from the breakdown of adenosine, has recently been shown to exert powerful anti-inflammatory effects both in vivo and in vitro. This study evaluated inosine as a potential therapy for colitis. Colitis was induced in mice by the administration of dextran sulfate sodium (DSS). Oral treatment with inosine was begun either before the onset of colitis or as a posttreatment once colitis was established. Evaluation of colon damage and inflammation was determined grossly (body wt, rectal bleeding), histologically, and biochemically (colon levels of MPO, MDA, and cytokines). DSS-induced colitis significantly increased inflammatory cell infiltration into the colon. DSS-induced colitis also increased colon levels of lipid peroxidation, cytokines, and chemokines. Inosine protected the colon from DSS-induced inflammatory cell infiltration and lipid peroxidation. Inosine also partially reduced these parameters in an experimental model of established colitis. Thus inosine treatment may be a potential therapy in colitis.
Keywords
Animals, Anticoagulants, Colitis/chemically induced, Colitis/drug therapy, Colon/metabolism, Cytokines/metabolism, Dextran Sulfate, Disease Models, Animal, Inosine/pharmacology, Male, Mice, Mice, Inbred BALB C, Survival Rate
Pubmed
Web of science
Create date
24/01/2008 17:01
Last modification date
20/08/2019 13:32
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