Pancreatic adenocarcinoma: the impact of preneoplastic lesion pattern on survival.

Details

Serval ID
serval:BIB_3C1B9862D745
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pancreatic adenocarcinoma: the impact of preneoplastic lesion pattern on survival.
Journal
Bioscience Trends
Author(s)
Flattet Y., Yamaguchi T., Andrejevic-Blant S., Halkic N.
ISSN
1881-7823 (Electronic)
ISSN-L
1881-7815
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
9
Number
6
Pages
402-406
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Pancreatic adenocarcinoma is associated with a very poor prognosis, characterized with a 5-year survival rate of only 5%. Surgery is the only curative treatment for selected patients. Nevertheless, recurrence is very frequent. Identifying prognostic factors is thus warranted. Like numerous other tumors, adenocarcinomas are preceded by preneoplastic lesions. The role and the impact of these lesions remain unclear. This study aimed to assess the impact of the preneoplastic lesion pattern and histo-morphological features, on survival after pancreatic resection. Thirty-five patients who underwent pancreatic resection for pancreatic adenocarcinoma were identified from a prospective database of a single center, between 2003 and 2008. We considered demographics, tumor characteristics and type of treatment. The major outcome was survival. Analyzes were separated into two groups, according to the preneoplastic lesions: Pancreatic intraepithelial neoplasia (PanIN)-related carcinomas and intracanalar papillary mucinous neoplasia (IPMN)-related carcinomas. The former were more frequent, accounting for 63% (22/35). Moreover, they displayed more aggressive features, with a higher tumor stage (p = 0.01) and higher rate of positive lymph nodes (p = 0.019). Lymphatic (p = 0.009) and perinervous (p = 0.019) invasions were also more frequent. Survival was negatively influenced by PanIN preneoplastic lesions (p = 0.015), T3-4 tumor stage (p = 0.038), positive lymph nodes (p = 0.044), lymphatic (p = 0.019) and vascular (p = 0.029) invasions. Pancreatic adenocarcinoma displays different behavior according to its preneoplastic lesion. Indeed, PanIN-related adenocarcinoma showed more aggressive features and lower survival rate. Preneoplastic lesions may represent predictive factors for survival. Their role and predictive value should be investigated more thoroughly.
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2016 18:41
Last modification date
20/08/2019 13:32
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