High levels of lung resident CD4+CD28null cells in COPD: implications of autoimmunity.

Details

Serval ID
serval:BIB_3BCD19B8372A
Type
Article: article from journal or magazin.
Collection
Publications
Title
High levels of lung resident CD4+CD28null cells in COPD: implications of autoimmunity.
Journal
Wiener klinische Wochenschrift
Author(s)
Hoetzenecker K., Mitterbauer A., Guenova E., Schweiger T., Altmann P., Zimmermann M., Hofbauer H., Beer L., Klepetko W., Ankersmit H.J.
ISSN
1613-7671 (Electronic)
ISSN-L
0043-5325
Publication state
Published
Issued date
03/2013
Peer-reviewed
Oui
Volume
125
Number
5-6
Pages
150-155
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Chronic obstructive pulmonary disease (COPD) is a worldwide burden and a major cause of death. Pathogenetic mechanisms underlying the disease are still largely unknown. However, a continuous toxic injury due to tobacco smoking leading to a self-maintaining inflammatory process is considered a key factor in the pathophysiology of the disease. Evidence that autoimmunity might be involved in the maintenance of COPD has been recently noticed with great interest.During the chronic phase of an autoimmune response, lymphocytes lose their costimulatory signals. Previously, CD4+CD28null cells were reported to be systemically heightened in COPD patients. However, a direct role of CD4+CD28null cells in the pathogenesis of COPD is still under discussion, since there is no evidence that CD4+CD28null cells originate from the lungs of diseased patients. Therefore, we evaluated lungs from end-stage COPD patients and compared the levels of tissue infiltrating CD4+CD28null cells to systemic levels. We could show that CD4+CD28null cells are present in high amounts in lung tissue obtained from COPD GOLD IV patients suggesting a direct involvement of those cells in the pathophysiology of COPD. Furthermore, purified lung-resident CD4+ cells showed a stable proliferative response to lung specific elastin and collagen.These results further corroborate the role of autoreactive CD4+ cells in the maintenance of the inflammatory destruction in COPD. Modulating CD4+ cell function might be a new promising tool for future therapeutic approaches.
Keywords
Adolescent, Adult, Aged, Autoimmunity/immunology, CD28 Antigens/immunology, CD4-Positive T-Lymphocytes/immunology, Female, Humans, Lung/immunology, Lung/pathology, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive/immunology, Pulmonary Disease, Chronic Obstructive/pathology
Pubmed
Web of science
Create date
27/08/2020 13:59
Last modification date
02/09/2020 5:26
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