Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.
Details
Serval ID
serval:BIB_3BC9F9915CC9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.
Journal
Head & neck
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
39
Number
10
Pages
2004-2015
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC.
Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors.
The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%).
Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.
Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors.
The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%).
Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.
Keywords
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell/mortality, Carcinoma, Squamous Cell/therapy, Carcinoma, Squamous Cell/virology, Chemoradiotherapy/methods, Female, Head and Neck Neoplasms/mortality, Head and Neck Neoplasms/therapy, Head and Neck Neoplasms/virology, Humans, Male, Middle Aged, Oropharyngeal Neoplasms/mortality, Oropharyngeal Neoplasms/pathology, Oropharyngeal Neoplasms/therapy, Oropharyngeal Neoplasms/virology, Papillomaviridae/genetics, Papillomavirus Infections/complications, Papillomavirus Infections/epidemiology, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Tissue Array Analysis, human papillomavirus, oropharynx, squamous cell cancer, surgery, survival
Pubmed
Web of science
Create date
12/07/2017 12:22
Last modification date
20/08/2019 13:31
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