The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.

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Serval ID
serval:BIB_3BBDA95027BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.
Journal
Human Molecular Genetics
Author(s)
Choquet H., Cavalcanti-Proença C., Lecoeur C., Dina C., Cauchi S., Vaxillaire M., Hadjadj S., Horber F., Potoczna N., Charpentier G., Ruiz J., Hercberg S., Maimaitiming S., Roussel R., Boenhnke M., Jackson A.U., Patsch W., Krempler F., Voight B.F., Altshuler D., Groop L., Thorleifsson G., Steinthorsdottir V., Stefansson K., Balkau B., Froguel P., Meyre D.
ISSN
1460-2083[electronic]
Publication state
Published
Issued date
2009
Volume
18
Number
13
Pages
2495-2501
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Abstract
A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes.
Keywords
Aged, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Type 2/epidemiology, Diabetes Mellitus, Type 2/genetics, Europe/epidemiology, European Continental Ancestry Group/genetics, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Natriuretic Peptide, Brain/genetics, Natriuretic Peptide, Brain/metabolism, Pedigree, Polymorphism, Single Nucleotide, Risk Factors
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Web of science
Open Access
Yes
Create date
09/02/2010 9:02
Last modification date
25/09/2019 6:08
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