Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_3B9B3D102119
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Winter birth: A factor of poor functional outcome in a Swiss early psychosis cohort
Journal
Schizophrenia Research
Author(s)
Restellini Romeo, Golay Philippe, Jenni Raoul, Baumann Philipp S., Alameda Luis, Allgäuer Larissa, Steullet Pascal, Abrahamyan Empson Lilith, Mebdouhi Nadir, Do Kim Quang, Conus Philippe, Dwir Daniella, Klauser Paul
ISSN
0920-9964
ISSN-L
0920-9964
Publication state
Published
Issued date
12/2024
Peer-reviewed
Oui
Volume
274
Pages
206-211
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Winter birth has consistently been identified as a risk factor for schizophrenia. This study aimed to determine whether individuals born during this season are also at higher risk for early psychosis and whether this is associated with distinct functional and clinical outcomes.
We conducted a prospective study on 222 patients during their early phase of psychosis in Switzerland, nested in the Treatment and Early Intervention in Psychosis (TIPP) cohort. We compared the birth trimesters of these patients with those of the general Swiss population. Additionally, we evaluated the Global Assessment of Functioning scale (GAF) and the Positive and Negative Syndrome Scale (PANSS) scores among patients born in winter (January to March) versus those born during the rest of the year during a three-year follow-up period.
A significantly higher proportion of patients experiencing early psychosis were born in winter compared to the general Swiss population. Patients born in winter had significantly lower GAF scores at 6 months, 24 months, and 36 months of follow-up, compared to patients born during the rest of the year. They also manifested fewer positive symptoms, as indicated by the PANSS positive subscale.
Birth in winter appears to be associated with a lower functional outcome and potentially distinct symptomatology in the early phase of psychosis.
Pubmed
Open Access
Yes
Create date
23/09/2024 8:14
Last modification date
10/10/2024 7:22
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