Recent developments in innervation imaging using iodine-123-metaiodobenzylguanidine scintigraphy in Lewy body diseases.

Details

Serval ID
serval:BIB_3B81BC5C1E58
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Recent developments in innervation imaging using iodine-123-metaiodobenzylguanidine scintigraphy in Lewy body diseases.
Journal
Neurological sciences
Author(s)
Treglia G., Cason E., Gabellini A., Giordano A., Fagioli G.
ISSN
1590-3478 (Electronic)
ISSN-L
1590-1874
Publication state
Published
Issued date
08/2010
Peer-reviewed
Oui
Volume
31
Number
4
Pages
417-422
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Radiolabeled metaiodobenzylguanidine (MIBG) is an analog of guanethidine and is taken up by the postganglionic presynaptic nerve endings. MIBG uptake in the heart correlates with adrenergic function, which can be reduced in Lewy body diseases. We described the recent developments in innervation imaging using (123)I-MIBG scintigraphy in Lewy body diseases including Parkinson's disease and dementia with Lewy bodies. Particularly, we underlined the role of MIBG scintigraphy in differential diagnosis of movement disorders. As described by recent studies, MIBG scintigraphy is a valuable diagnostic tool for differentiation between Lewy body diseases and parkinsonian syndromes or other movement disorders with parkinsonism. Furthermore, this method may provide a powerful differential diagnostic tool between dementia with Lewy bodies and Alzheimer's disease. We also reported the results of clinical investigations about the correlation between characteristics of Parkinson's disease and myocardial MIBG uptake.

Keywords
3-Iodobenzylguanidine/pharmacokinetics, Diagnosis, Differential, Extrapyramidal Tracts/diagnostic imaging, Heart/diagnostic imaging, Humans, Lewy Bodies/diagnostic imaging, Lewy Bodies/metabolism, Movement Disorders/diagnosis, Myocardium/metabolism, Parkinson Disease/diagnosis, Parkinson Disease/diagnostic imaging, Radionuclide Imaging, Radiopharmaceuticals/pharmacokinetics
Pubmed
Web of science
Create date
20/08/2017 21:21
Last modification date
20/08/2019 13:31
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