Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice.

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Serval ID
serval:BIB_3B80EA47EE7C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice.
Journal
Scientific reports
Author(s)
Li S., Franken P., Vassalli A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
19/10/2018
Peer-reviewed
Oui
Volume
8
Number
1
Pages
15474
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Noradrenaline (NA) and hypocretins/orexins (HCRT), and their receptors, dynamically modulate the circuits that configure behavioral states, and their associated oscillatory activities. Salient stimuli activate spiking of locus coeruleus noradrenergic (NA <sup>LC</sup> ) cells, inducing NA release and brain-wide noradrenergic signalling, thus resetting network activity, and mediating an orienting response. Hypothalamic HCRT neurons provide one of the densest input to NA <sup>LC</sup> cells. To functionally address the HCRT-to-NA connection, we selectively disrupted the Hcrtr1 gene in NA neurons, and analyzed resulting (Hcrtr1 <sup>Dbh-CKO</sup> ) mice', and their control littermates' electrocortical response in several contexts of enhanced arousal. Under enforced wakefulness (EW), or after cage change (CC), Hcrtr1 <sup>Dbh-CKO</sup> mice exhibited a weakened ability to lower infra-θ frequencies (1-7 Hz), and mount a robust, narrow-bandwidth, high-frequency θ rhythm (~8.5 Hz). A fast-γ (55-80 Hz) response, whose dynamics closely parallelled θ, also diminished, while β/slow-γ activity (15-45 Hz) increased. Furthermore, EW-associated locomotion was lower. Surprisingly, nestbuilding-associated wakefulness, inversely, featured enhanced θ and fast-γ activities. Thus HCRT-to-NA signalling may fine-tune arousal, up in alarming conditions, and down during self-motivated, goal-driven behaviors. Lastly, slow-wave-sleep following EW and CC, but not nestbuilding, was severely deficient in slow-δ waves (0.75-2.25 Hz), suggesting that HCRT-to-NA signalling regulates the slow-δ rebound characterizing sleep after stress-associated arousal.
Keywords
Adrenergic Neurons/physiology, Animals, Behavior, Animal, Brain/physiology, Gamma Rhythm, Locomotion, Mice, Mice, Knockout, Nesting Behavior, Orexin Receptors/deficiency, Orexins/metabolism, Theta Rhythm
Pubmed
Web of science
Open Access
Yes
Create date
24/10/2018 9:22
Last modification date
27/10/2019 7:11
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