Opiate concentrations in human head, axillary, and pubic hair.

Details

Serval ID
serval:BIB_3B522D2ED754
Type
Article: article from journal or magazin.
Collection
Publications
Title
Opiate concentrations in human head, axillary, and pubic hair.
Journal
Journal of Forensic Sciences
Author(s)
Kintz P., Mangin P.
ISSN
0022-1198[print], 0022-1198[linking]
Publication state
Published
Issued date
1993
Volume
38
Number
3
Pages
657-662
Language
english
Abstract
The concentrations of morphine and codeine were investigated in hair from the head, axillary and pubic regions obtained from 12 fatal heroin cases. Hair preparation involves a decontamination procedure in dichloromethane at 37 degrees C for 15 min, solubilization in sodium hydroxyde at 100 degrees C for 5 min, neutralization with hydrochloric acid and centrifugation. After extraction in chloroform-isopropanol-n-heptane (50:17:33; v/v) at pH 9.2, drugs were derivatized with BSTFA + 1% TMCS and separated on a 12-m BP-5 capillary column. Quantification was done by GC/MS using selected ion monitoring. The highest morphine concentrations were found in pubic hair (0.80 to 41.34 ng/mg), followed by hair of the head (0.62 to 27.10 ng/mg), and axillary hair (0.40 to 24.20 ng/mg). Codeine was also detected in all samples, and the codeine-to-morphine ratios ranged from 0.069 to 0.273. The differences observed in drug concentration in the 3 types of hair are discussed in the light of the existing literature.
Keywords
Adult, Axilla, Codeine/analysis, Codeine/poisoning, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Head, Humans, Male, Morphine/analysis, Morphine/poisoning, Overdose/pathology
Pubmed
Create date
18/10/2010 13:59
Last modification date
20/08/2019 13:31
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