Hypocomplementemic panniculitis with paraprotein

Details

Serval ID
serval:BIB_3B3CCBB92E75
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hypocomplementemic panniculitis with paraprotein
Journal
Journal of Rheumatology
Author(s)
Kondo-Oestreicher  M., Chizzolini  C., Tissot  J. D., Girardet  C., Schiffer  E., Reymond  J. M., Schifferli  J. A.
ISSN
0315-162X (Print)
Publication state
Published
Issued date
04/2000
Volume
27
Number
4
Pages
1091-5
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Abstract
Two episodes of severe panniculitis accompanied by fever and an acute phase response were the main clinical features in a patient who had an unusual IgG kappa paraprotein. Both episodes responded promptly to steroids. Complement proteins of the early classical pathway were depleted in the patient's serum, and in vitro experiments indicated that the IgG kappa paraprotein activated complement directly. The association of recurrent panniculitis and paraproteinemia-hypocomplementemia has been described in 2 other patients. It should be recognized since its response to steroids is immediate.
Keywords
Acute-Phase Reaction Biopsy Complement System Proteins/*metabolism Humans Immunoglobulin G/*blood Immunoglobulin kappa-Chains/blood Male Middle Aged Panniculitis/immunology/*pathology/radiography Paraproteinemias/immunology/*pathology/radiography Tomography, X-Ray Computed
Pubmed
Web of science
Create date
25/01/2008 15:34
Last modification date
20/08/2019 13:31
Usage data