Myokardschutz: Ist die retrograde der antegraden Perfusion gleichwertig? [Myocardial protection: is retrograde equal to antegrade perfusion?]

Details

Serval ID
serval:BIB_3AEBCB1A5CD5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Myokardschutz: Ist die retrograde der antegraden Perfusion gleichwertig? [Myocardial protection: is retrograde equal to antegrade perfusion?]
Journal
Helvetica Chirurgica Acta
Author(s)
Tonz  M., Freiburghaus  A. U., Redha  F., Schneider  J., von Segesser  L. K., Turina  M.
ISSN
0018-0181
Publication state
Published
Issued date
12/1993
Volume
60
Number
3
Pages
435-8
Notes
Comparative Study
English Abstract
Journal Article --- Old month value: Dec
Abstract
The adequacy of retrograde delivery of cardioplegic solution to the right ventricle ist controversial. To evaluate this issue, we excised the plegic heart in 11 bovine experiments and infused an India ink solution (10 ml of India ink in 300 ml NaCl 0.9%) into the coronary sinus (n = 7) at a pressure of 60 cm H2O and into the aortic root (n = 4) at a pressure of 120 cm H2O. After fixation, the ventricles were cut in 11 transversal slices. The portion of coloured (= perfused) ventricular myocardium was calculated with computer-aided morphometric analysis. With antegrade infusion, 95 +/- 5% (mean +/- standard deviation) of the left ventricular volume (left ventricular free wall plus interventricular septum) was stained, with retrograde infusion 94 +/- 3%. Perfusion of the right ventricle was significantly lower with retrograde infusion (antegrade infusion 93 +/- 8%, retrograde 45 +/- 13%, p < 0.001), especially in the basal segments (basal vs. apical: 16 +/- 26% vs. 82 +/- 5%, p < 0.001). The adequate delivery of retrograde infusion to the left ventricle and septum allows good left ventricular myocardial protection with retrograde cardioplegia. Because the retrograde delivery to the right ventricle is markedly inadequate and nonuniform, the quality of right ventricular protection with retrograde cardioplegia has to be questioned.
Keywords
Animals Cardioplegic Solutions/*administration & dosage Cattle Heart Arrest, Induced/*methods Myocardial Ischemia/*pathology Myocardium/*pathology Ventricular Function, Left/physiology Ventricular Function, Right/physiology
Pubmed
Web of science
Create date
14/02/2008 14:16
Last modification date
20/08/2019 13:30
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