Recurrence of keratoconus characteristics: a clinical and histologic follow-up analysis of donor grafts.

Details

Serval ID
serval:BIB_3AC28BE909DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Recurrence of keratoconus characteristics: a clinical and histologic follow-up analysis of donor grafts.
Journal
Ophthalmology
Author(s)
Bourges J.L., Savoldelli M., Dighiero P., Assouline M., Pouliquen Y., BenEzra D., Renard G., Behar-Cohen F.
ISSN
0161-6420 (Print)
ISSN-L
0161-6420
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
110
Number
10
Pages
1920-1925
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
PURPOSE: To report on clinical corneal topography, histopathologic analysis, and fine structure findings in failed grafts after penetrating keratoplasty (PK) for keratoconus (KC).
DESIGN: Retrospective, consecutive, interventional case series with histologic and clinical correlation.
PARTICIPANTS: Twelve corneal buttons were obtained from consecutive patients undergoing repeated PK 10 to 28 years after the initial PK for KC. The indication for regrafting was endothelial deficiency in seven cases, irreversible immune graft rejection in two cases, and corneal ectasia in three cases.
METHODS: Removed corneal buttons were examined by light and transmission electron microscopy. A potential correlation between the clinical and videokeratoscopic findings and the microscopic structural observations was analyzed.
RESULTS: Preoperative simulated keratometry measured by TMS-1 (Tomey, New York, NY) or EyeSys CAS (EyeSys Technology, Houston, TX) ranged from 49.8 to 66.1 diopters. A pattern compatible with KC characteristics was observed in all cases. Fine structure analysis revealed Bowman's layer disruption or folds and stromal deposits in all corneal buttons. However, central corneal thinning was not present in any of the removed buttons.
CONCLUSIONS: Structure changes compatible with the diagnosis of KC were observed in all donor buttons many years after PK on KC recipients. Recurrence of the KC characteristics may result from graft repopulation by recipients' keratocytes, aging of the grafted tissue, or both.
Keywords
Adult, Aged, Aged, 80 and over, Cornea/pathology, Cornea/surgery, Corneal Topography, Female, Follow-Up Studies, Graft Rejection/diagnosis, Humans, Keratoconus/diagnosis, Keratoconus/surgery, Keratoplasty, Penetrating, Male, Middle Aged, Recurrence, Reoperation, Retrospective Studies, Tissue Donors
Pubmed
Web of science
Create date
19/11/2013 11:50
Last modification date
20/08/2019 13:30
Usage data