Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy.

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State: Public
Version: author
Serval ID
serval:BIB_3AB83F3EF5C8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Atypical association of semantic dementia, corticobasal syndrome, and 4R tauopathy.
Journal
Neurocase
Author(s)
Clerc M.T., Deprez M., Leuba G., Lhermitte B., Lopez U., von Gunten A.
ISSN
1465-3656 (Electronic)
ISSN-L
1355-4794
Publication state
Published
Issued date
2015
Volume
21
Number
1
Pages
1-15
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
A 57-year-old male with no family history was diagnosed with semantic dementia. He also showed some unusual cognitive features such as episodic memory and executive dysfunctions, spatial disorientation, and dyscalculia. Rapidly progressive cognitive and physical decline occurred. About 1.5 years later, he developed clinical features of a corticobasal syndrome. He died at the age of 60. Brain autopsy revealed numerous 4R-tau-positive lesions in the frontal, parietal and temporal lobes, basal ganglia, and brainstem. Neuronal loss was severe in the temporal cortex. Such association of semantic dementia with tauopathy and corticobasal syndrome is highly unusual. These findings are discussed in the light of current knowledge about frontotemporal lobar degeneration.
Pubmed
Web of science
Create date
10/12/2013 13:49
Last modification date
20/08/2019 13:30
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