Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy.

Details

Serval ID
serval:BIB_3AAC2EC410D2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy.
Journal
Journal of Neurovirology
Author(s)
Gheuens S., Fellay J., Goldstein D.B., Koralnik I.J.
ISSN
1538-2443 (Electronic)
ISSN-L
1355-0284
Publication state
Published
Issued date
2010
Volume
16
Number
1
Pages
41-47
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., ExtramuralPublication Status: ppublish
Abstract
Because human leukocyte antigen (HLA) associations with various infectious diseases have recently been reported, we examined the role of HLA class I alleles in the development of progressive multifocal leukoencephalopathy (PML) or its outcome in 152 patients, including 123 Caucasians and 29 African Americans. Compared to a human immunodeficiency virus positive (HIV+) control population, we observed decreased frequency of HLA-A3 (P = 0.03) in the Caucasian PML group, whereas B18 (P = 0.02), was more frequent. No such difference was found among African American PML patients. We then sought to characterize differences in HLA between PML progressors, whose survival doesn't exceed 1 year, and survivors. Caucasian survivors were less likely to harbor A68 (P = 0.01), whereas African American survivors less frequently displayed Cw4 (P = .01). However, none of these differences reached statistical significance after Bonferroni correction for multiple testing. Further investigations are needed to assess the role of genetics in the incidence of PML or its outcome. Physicians may exercise caution in the use of immunomodulatory medications in patients whose genetic background is associated with an increased risk of PML.
Keywords
AIDS-Related Opportunistic Infections/genetics, AIDS-Related Opportunistic Infections/immunology, African Americans, Disease Progression, European Continental Ancestry Group, Gene Frequency, Genetic Predisposition to Disease, HIV, HLA-A Antigens/classification, HLA-A Antigens/genetics, HLA-A3 Antigen/classification, HLA-A3 Antigen/genetics, HLA-B Antigens/classification, HLA-B Antigens/genetics, HLA-B18 Antigen, HLA-C Antigens/classification, HLA-C Antigens/genetics, Histocompatibility Antigens Class I/genetics, Histocompatibility Antigens Class I/immunology, Humans, JC Virus, Leukoencephalopathy, Progressive Multifocal/genetics, Leukoencephalopathy, Progressive Multifocal/immunology, Serotyping
Pubmed
Web of science
Create date
01/03/2012 15:14
Last modification date
20/08/2019 13:30
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