Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_3A909E201383
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bone metabolism dynamics in the early post-transplant period following kidney and liver transplantation.
Journal
PloS one
Author(s)
Schreiber P.W., Bischoff-Ferrari H.A., Boggian K., Bonani M., van Delden C., Enriquez N., Fehr T., Garzoni C., Hirsch H.H., Hirzel C., Manuel O., Meylan P., Saleh L., Weisser M., Mueller N.J.
Working group(s)
Swiss Transplant Cohort Study (STCS)
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
13
Number
1
Pages
e0191167
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)2 vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P<0.001) and median intact parathyroid hormone levels decreased by 68.4% (from 208.7 to 66.0 ng/l; P<0.001). Median β-Crosslaps (CTx) and total procollagen type 1 amino-terminal propeptide (P1NP) decreased by 65.1% (from 1.32 to 0.46ng/ml; P<0.001) and 60.6% (from 158.2 to 62.3ng/ml; P<0.001), respectively. Kidney recipients with incident fractures had significantly lower levels of 1, 25-(OH)2 vitamin D at time of transplantation and of intact parathyroid hormone 6 months post-transplant. Among 70 liver recipients, 25-OH vitamin D, 1, 25-(OH)2 vitamin D and intact parathyroid hormone levels were not significantly altered between peri-transplant and 6 months post-transplant. Contrary to kidney recipients, median CTx increased by 60.0% (from 0.45 to 0.72 ng/ml; P = 0.002) and P1NP by 49.3% (from 84.0 to 125.4ng/ml; P = 0.001) in the longitudinal course. Assessed biomarkers didn't differ between liver recipients with and without fractures. To conclude, the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period. After kidney transplantation a significant gain in 1, 25-(OH)2 vitamin D combined with a decline in iPTH, CTx and P1NP, whereas after liver transplantation an increase in CTx and P1NP were characteristic.

Keywords
Adult, Biomarkers/blood, Bone Density, Bone Remodeling/physiology, Bone and Bones/metabolism, Collagen Type I/blood, Female, Fractures, Bone/etiology, Glomerular Filtration Rate, Humans, Kidney Transplantation/adverse effects, Liver Transplantation/adverse effects, Male, Middle Aged, Parathyroid Hormone/blood, Peptide Fragments/blood, Peptides/blood, Phosphates/blood, Procollagen/blood, Prospective Studies, Vitamin D/analogs & derivatives, Vitamin D/blood
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2018 11:14
Last modification date
20/08/2019 13:30
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