Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors.

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Serval ID
serval:BIB_3A8C502C403F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors.
Journal
Chemical Senses
Author(s)
Lacroix M.C., Caillol M., Durieux D., Monnerie R., Grebert D., Pellerin L., Repond C., Tolle V., Zizzari P., Baly C.
ISSN
1464-3553 (Electronic)
ISSN-L
0379-864X
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
40
Number
8
Pages
537-556
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Obesity is associated with chronic food intake disorders and binge eating. Food intake relies on the interaction between homeostatic regulation and hedonic signals among which, olfaction is a major sensory determinant. However, its potential modulation at the peripheral level by a chronic energy imbalance associated to obese status remains a matter of debate. We further investigated the olfactory function in a rodent model relevant to the situation encountered in obese humans, where genetic susceptibility is juxtaposed on chronic eating disorders. Using several olfactory-driven tests, we compared the behaviors of obesity-prone Sprague-Dawley rats (OP) fed with a high-fat/high-sugar diet with those of obese-resistant ones fed with normal chow. In OP rats, we reported 1) decreased odor threshold, but 2) poor olfactory performances, associated with learning/memory deficits, 3) decreased influence of fasting, and 4) impaired insulin control on food seeking behavior. Associated with these behavioral modifications, we found a modulation of metabolism-related factors implicated in 1) electrical olfactory signal regulation (insulin receptor), 2) cellular dynamics (glucorticoids receptors, pro- and antiapoptotic factors), and 3) homeostasis of the olfactory mucosa and bulb (monocarboxylate and glucose transporters). Such impairments might participate to the perturbed daily food intake pattern that we observed in obese animals.
Keywords
Animals, Behavior, Animal, Body Weight, Diet, High-Fat, Eating, Energy Metabolism, Glucose Transport Proteins, Facilitative/genetics, Glucose Transport Proteins, Facilitative/metabolism, Insulin/metabolism, Male, Models, Animal, Obesity/etiology, Obesity/metabolism, Odors, Olfactory Bulb/metabolism, Olfactory Mucosa/metabolism, Rats, Rats, Sprague-Dawley, Receptor, Insulin/genetics, Receptor, Insulin/metabolism, Receptors, Leptin/genetics, Receptors, Leptin/metabolism, Smell/physiology
Pubmed
Web of science
Open Access
Yes
Create date
09/11/2015 9:54
Last modification date
25/09/2019 6:08
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