Tumor architecture exerts no bias on nuclear grading in breast cancer diagnosis.

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State: Public
Version: Final published version
Serval ID
serval:BIB_3A7F5DD5E37C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tumor architecture exerts no bias on nuclear grading in breast cancer diagnosis.
Journal
Virchows Archiv : An International Journal of Pathology
Author(s)
Mora B., Bombari D., Schaefer S.C., Schmidt M., Delaloye J.F., Mast F., Lehr H.A.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Publication state
Published
Issued date
2012
Volume
461
Number
4
Pages
399-403
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
We recently reported that nuclear grading in prostate cancer is subject to a strong confirmation bias induced by the tumor architecture. We now wondered whether a similar bias governs nuclear grading in breast carcinoma. An unannounced test was performed at a pathology conference. Pathologists were asked to grade nuclei in a PowerPoint presentation. Circular high power fields of 27 invasive ductal carcinomas were shown, superimposed over low power background images of either tubule-rich or tubule-poor carcinomas. We found (a) that diagnostic reproducibility of nuclear grades was poor to moderate (weighed kappa values between 0.07 and 0.54, 27 cases, 44 graders), but (b) that nuclear grades were not affected by the tumor architecture. We speculate that the categorized grading in breast cancer, separating tubule formation, nuclear pleomorphism, and mitotic figure counts in a combined three tier score, prevents the bias that architecture exerts on nuclear grades in less well-controlled situations.
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2012 18:08
Last modification date
20/08/2019 13:30
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