Clinicobiological progression and prognosis of oral squamous cell carcinoma in relation to the tumor invasive front: impact on prognosis

Details

Serval ID
serval:BIB_3A41D8556737
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinicobiological progression and prognosis of oral squamous cell carcinoma in relation to the tumor invasive front: impact on prognosis
Journal
Acta Oto-laryngologica
Author(s)
Sandu K., Nisa L., Monnier P., Simon C., Andrejevic-Blant S., Bron L.
ISSN
1651-2251 (Electronic)
ISSN-L
0001-6489
Publication state
Published
Issued date
2014
Volume
134
Number
4
Pages
416-424
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
CONCLUSION: There are several factors that influence the final outcome when treating oral squamous cell carcinoma (OSCC). Invasive front phenomena and more importantly their clinicopathological translation can have a direct impact on survival, and subsequently on the decision for an adjuvant treatment.
OBJECTIVES: In recent years, the concept of tumor-host interaction has been the subject of substantial efforts in cancer research. Tumoral behavior may be better understood when studying the changes occurring at the tumor-host interface. This study evaluated the influence of several clinicopathological features on the outcome of OSCCs.
METHODS: The clinical records and pathology specimens of 54 patients with OSCC treated by primary resection were reviewed retrospectively. The pathologic features reviewed were: invasive front grading (IFG), stromal reaction, lymphovascular invasion (LVI), perineural invasion (PNI), margin status, and depth of invasion.
RESULTS: High IFGs had a significant relationship with pT status and pN status. High IFGs were strongly correlated with nodal metastases (odds ratio (OR) = 4.77; confidence interaval (CI) = 1.37-16.64). Concerning survival, IFG had a strong impact on disease-free survival in patients treated unimodally, as did the depth of invasion in the same group. Lymphovascular involvement was found to have a negative impact on overall survival in patients treated multimodally.
Pubmed
Web of science
Create date
25/04/2014 16:29
Last modification date
20/08/2019 13:29
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