Antenatal corticosteroids and outcomes in gastroschisis: A multicenter retrospective cohort study.

Details

Serval ID
serval:BIB_3A1C6D02E343
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antenatal corticosteroids and outcomes in gastroschisis: A multicenter retrospective cohort study.
Journal
Prenatal diagnosis
Author(s)
Carnaghan H., James C.P., Charlesworth P.B., Ghionzoli M., Pereira S., Elkhouli M., Baud D., De Coppi P., Ryan G., Shah P.S., Davenport M., David A.L., Pierro A., Eaton S.
Working group(s)
Gastroschisis Study Group
ISSN
1097-0223 (Electronic)
ISSN-L
0197-3851
Publication state
Published
Issued date
07/2020
Peer-reviewed
Oui
Volume
40
Number
8
Pages
991-997
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In gastroschisis, there is evidence to suggest that gut dysfunction develops secondary to bowel inflammation; we aimed to evaluate the effect of maternal antenatal corticosteroids administered for obstetric reasons on time to full enteral feeds in a multicenter cohort study of gastroschisis infants.
A three center, retrospective cohort study (1992-2013) with linked fetal/neonatal gastroschisis data was conducted. The primary outcome measure was time to full enteral feeds (a surrogate measure for bowel function) and secondary outcome measure was length of hospital stay. Analysis included Mann-Whitney and Cox regression.
Of 500 patients included in the study, 69 (GA at birth 34 [25-38] weeks) received antenatal corticosteroids and 431 (GA at birth 37 [31-41] weeks) did not. Antenatal corticosteroids had no effect on the rate of reaching full feeds (Hazard ratio HR 1.0 [95% CI: 0.8-1.4]). However, complex gastroschisis (HR 0.3 [95% CI: 0.2-0.4]) was associated with an increased time to reach full feeds and later GA at birth (HR 1.1 per week increase in GA [95% CI: 1.1-1.2]) was associated with a decreased time to reach full feeds.
Maternal antenatal corticosteroids use, under current antenatal steroid protocols, in gastroschisis is not associated with an improvement in neonatal outcomes such as time to full enteral feeds or length of hospital stay.
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2020 20:53
Last modification date
24/10/2020 5:21
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