Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla.

Details

Serval ID
serval:BIB_39F6D794D851
Type
Article: article from journal or magazin.
Collection
Publications
Title
Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla.
Journal
Magnetic Resonance in Medicine
Author(s)
Gruetter R., Garwood M., Uğurbil K., Seaquist E.R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Publication state
Published
Issued date
1996
Volume
36
Number
1
Pages
1-6
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish. PDF type: Communication
Abstract
Measurement of the resonances of glucose between 3.2 and 3.9 ppm in 1H NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites. The H1 resonance of alpha-D-glucose at 5.23 ppm is resolved from other metabolite peaks, but potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits to suppress the water signal sufficiently to reliably detect glucose directly at 5.23 ppm by 1H MRS and the estimated peak intensity is consistent with previous 13C NMR quantification.
Keywords
Blood Glucose/analysis, Body Water/metabolism, Brain/metabolism, Carbon Isotopes, Creatine/metabolism, Glucose/administration & dosage, Glucose/metabolism, Humans, Hydrogen, Hyperglycemia/blood, Infusions, Intravenous, Inositol/metabolism, Magnetic Resonance Spectroscopy/diagnostic use, Occipital Lobe/metabolism, Phantoms, Imaging, Reproducibility of Results, Signal Processing, Computer-Assisted
Pubmed
Web of science
Create date
04/08/2010 15:28
Last modification date
20/08/2019 13:29
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