Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies.

Details

Serval ID
serval:BIB_39953DE1C692
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies.
Journal
Scientific reports
Author(s)
Carmeli C., Kutalik Z., Mishra P.P., Porcu E., Delpierre C., Delaneau O., Kelly-Irving M., Bochud M., Dhayat N.A., Ponte B., Pruijm M., Ehret G., Kähönen M., Lehtimäki T., Raitakari O.T., Vineis P., Kivimäki M., Chadeau-Hyam M., Dermitzakis E., Vuilleumier N., Stringhini S.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
04/02/2021
Peer-reviewed
Oui
Volume
11
Number
1
Pages
3100
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.
Pubmed
Web of science
Open Access
Yes
Create date
27/01/2021 10:52
Last modification date
27/03/2021 7:32
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