Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis.

Details

Serval ID
serval:BIB_398BBBCA63B0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis.
Journal
International journal of molecular sciences
Author(s)
Graille M., Wild P., Sauvain J.J., Hemmendinger M., Guseva Canu I., Hopf N.B.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
26/05/2020
Peer-reviewed
Oui
Volume
21
Number
11
Pages
3743
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration, they can oxidize proteins, lipids, and DNA. DNA damage is usually repaired, and the oxidized products are excreted in urine. 8-hydroxy-2-deoxyguanosine is considered a biomarker for oxidative damage of DNA. It is needed to define background ranges for 8-OHdG, to use it as a measure of oxidative stress overproduction. We established a standardized protocol for a systematic review and meta-analysis to assess background ranges for urinary 8-OHdG concentrations in healthy populations. We computed geometric mean (GM) and geometric standard deviations (GSD) as the basis for the meta-analysis. We retrieved an initial 1246 articles, included 84 articles, and identified 128 study subgroups. We stratified the subgroups by body mass index, gender, and smoking status reported. The pooled GM value for urinary 8-OHdG concentrations in healthy adults with a mean body mass index (BMI) ≤ 25 measured using chemical methods was 3.9 ng/mg creatinine (interquartile range (IQR): 3 to 5.5 ng/mg creatinine). A significant positive association was observed between smoking and urinary 8-OHdG concentrations when measured by chemical analysis. No gender effect was observed.
Keywords
8-OHdG, Biomarker, Meta-analysis, Oxidative stress, Systematic review
Pubmed
Web of science
Open Access
Yes
Create date
04/06/2020 10:24
Last modification date
23/02/2021 7:26
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