Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery.
Details
Serval ID
serval:BIB_393D5C13F9D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery.
Journal
Neurology
Working group(s)
Predistim Study Group
Contributor(s)
Moreau D.C., Defebvre P.L., Carriere D.N., Grolez D.G., Baille D.G., Kreisler D., Jean-Pierre Pruvo P., Leclerc P., Lopes D.R., Viard D.R., Kuchcinski D.G., Dumont M.J., Dujardin P.K., Delliaux M.M., Brion M.M., Touzet D.G., Reyns P.N., Delval P.A., Santraine M.V., Pleuvret M.M., Dautrevaux M.N., Laugeais M.V., Ouk T., Potey C., Leclercq C., Gers E., Duhamel A., Djemmane L., Duflot F., Corvol Marie-Vidailhet J.C., Hainque E., Welter M.L., Lacomblez L., Grabli D., Roze E., Worbe Y., Delorme C., You H., Ihle J., GuimeraesCosta R., CormierDequaire F., Méneret A., Hartmann A., Mariani L.L., Lehericy S., Czernecki V., Pineau F., Bozon F., Huiban C., Benchetrit E., Karachi C., Navarro S., Cornu P., Welaratne A., Mantisi L., Jarry N., Aix S., Lefort C., Rouaud D.T., Damier P.P., Derkinderen P.P., Anne-Gaelle Corbille D., CalvierAuffray D.E., Rocher L., Deruet A.L., Sylvie D.R., Vincent D.R., Séverine L.D., Marques D.A., Debilly D.B., Durif P.F., Derost D.P., Beal D.C., Chassain C., Delaby L., Vidal T., Lemaire PJJ, Rieu I., Durand E., Sophie D.D., Leh D.F., Bonnet D.A., Vérin P.M., Jean-Christophe Ferré D., Houvenaghel J.F., Haegelen P.C., Kestens F., Ory S., Girodana D.C., Marsé D.C., Mondot D.L., Giordana D.B., Kardous D.R., Bailet B., Joly H., Fontaine D.D., Leplus D.A., Faustini A., Ferrier V., Burbaud P.P., DamonPerriere D.N., Meissner P.W., Tison P.F., Bannier D.S., Krim D.E., Guehl P.D., Molinier-Blossier D.S., Ollivier D.M., Lacoste D.M., Auzou N., Bonnet M., Cuny P.E., Engelhardt D.J., Branchard O., Huet C., Blanchard J., Eusebio P.A., Jean-Philippe Azulay P., Witjas D.T., Fluchère D.F., Grimaldi D.S., Girard P.N., Benchetrit E., Delfini M., Carron D.R., Regis P.J., Spatola D.G., Magnaudet C., Solène D.A., Isabelle D.B., Olivier D.C., Jean Luc P.H., Remy P.G., Anne F., Manssouri A., Sophie B., Philippe D.R., Philippe D.C., Philippe D.P., Benoit P.B., Emilie R., Annie G., Maltete P.D., Lefaucheur D.R., Fetter D.D., Magne D.N., Bioux S., Loubeyre M., Bliaux E., Pouliquen D., Derrey P.S., Vernon M.L., Ziegler D.F., Olivier P.R., Brefel Courbon D.C., Ory Magne D.F., Simonetta Moreau D.M., Arbus P.C., Bonneville P.F., Albert Lotterie D.J., Sarrail M., Chaynes P.P., Caire P.F., Harroch E., Anheim P.M., LaghaBoukbiza D.O., Tranchant P.C., Gebus D.O., Montaut D.S., Kremer D.S., Longato N., Phillips C., Voirin D.J., Marie des Neiges Santin D., Chaussemy D.D., Mengin D.A., Krystkowiak P.P., Tir D.M., Jean-Marc Constans P., Wannepain S., Seling A., Lefranc D.M., Blin S., Schuler B., Thobois P.S., Danaila D.T., Laurencin D.C., Berthezene P.Y., Ameli D.R., Klinger H., Polo D.G., Simon D.E., Mertens D.P., Nunes A., Metereau E., Hopes Dr D.L., Schmitt E., Meyer M., Dillier C., Colnat P.S., Chatelain A., Philippe Brandel D.J., Hubsch D.C., Karsenti D.P., Lebouteux D.M., Ziegler D.M., Delmaire D.C., Savatowky D.J., Vrillac J., Nakache C., D'Hardemare D.V., Belamri L., Bourdain D.F., Afanassiev D.V., Graveleau D.P., Decrocq D.C., Boulin D.A., Dupuy V E., Gardel D.B., Jarraya P.B., Lopez D., Fruit C., Gay D., Bonice R., El Mountassir F., Fischer C., Mangin J.F., Chupin M., Cointepas Y., Accart B., Gelé P., Fievet F., Chabel M., Derenaucourt V., Facon L., Njosse Y.T., Deplanque D.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Publication state
Published
Issued date
16/11/2021
Peer-reviewed
Oui
Volume
97
Number
20
Pages
e1994-e2006
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To determine whether patients with Parkinson disease (PD) eligible for subthalamic nucleus deep brain stimulation (STN-DBS) with probable REM sleep behavior disorder (RBD) preoperatively could be more at risk of poorer motor, nonmotor, and quality of life outcomes 12 months after surgery compared to those without RBD.
We analyzed the preoperative clinical profile of 448 patients with PD from a French multicentric prospective study (PREDISTIM) according to the presence or absence of probable RBD based on the RBD Single Question and RBD Screening Questionnaire. Among the 215 patients with PD with 12 months of follow-up after STN-DBS, we compared motor, cognitive, psycho-behavioral profile, and quality of life outcomes in patients with (pre-opRBD+) or without (pre-opRBD-) probable RBD preoperatively.
At preoperative evaluation, pre-opRBD+ patients were older (61 ± 7.2 vs 59.5 ± 7.7 years; p = 0.02), had less motor impairment (Movement Disorder Society-sponsored version of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] III "off": 38.7 ± 16.2 vs 43.4 ± 7.1; p = 0.03) but more nonmotor symptoms on daily living activities (MDS-UPDRS I: 12.6 ± 5.5 vs 10.7 ± 5.3; p < 0.001), had more psychobehavioral manifestations (Ardouin Scale of Behavior in Parkinson's Disease total: 7.7 ± 5.1 vs 5.1 ± 0.4; p = 0.003), and had worse quality of life (Parkinson's Disease Questionnaire-39: 33 ± 12 vs 29 ± 12; p = 0.03), as compared to pre-opRBD- patients. Both pre-opRBD+ and pre-opRBD- patients had significant MDS-UPDRS IV score decrease (-37% and -33%, respectively), MDS-UPDRS III "med 'off'/stim 'on'" score decrease (-52% and -54%), and dopaminergic treatment decrease (-52% and -49%) after surgery, with no between-group difference. There was no between-group difference for cognitive and global quality of life outcomes.
In patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with a different clinical outcome 1 year after neurosurgery.
NCT02360683.
This study provides Class II evidence that in patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with poorer outcomes 1 year post surgery.
We analyzed the preoperative clinical profile of 448 patients with PD from a French multicentric prospective study (PREDISTIM) according to the presence or absence of probable RBD based on the RBD Single Question and RBD Screening Questionnaire. Among the 215 patients with PD with 12 months of follow-up after STN-DBS, we compared motor, cognitive, psycho-behavioral profile, and quality of life outcomes in patients with (pre-opRBD+) or without (pre-opRBD-) probable RBD preoperatively.
At preoperative evaluation, pre-opRBD+ patients were older (61 ± 7.2 vs 59.5 ± 7.7 years; p = 0.02), had less motor impairment (Movement Disorder Society-sponsored version of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] III "off": 38.7 ± 16.2 vs 43.4 ± 7.1; p = 0.03) but more nonmotor symptoms on daily living activities (MDS-UPDRS I: 12.6 ± 5.5 vs 10.7 ± 5.3; p < 0.001), had more psychobehavioral manifestations (Ardouin Scale of Behavior in Parkinson's Disease total: 7.7 ± 5.1 vs 5.1 ± 0.4; p = 0.003), and had worse quality of life (Parkinson's Disease Questionnaire-39: 33 ± 12 vs 29 ± 12; p = 0.03), as compared to pre-opRBD- patients. Both pre-opRBD+ and pre-opRBD- patients had significant MDS-UPDRS IV score decrease (-37% and -33%, respectively), MDS-UPDRS III "med 'off'/stim 'on'" score decrease (-52% and -54%), and dopaminergic treatment decrease (-52% and -49%) after surgery, with no between-group difference. There was no between-group difference for cognitive and global quality of life outcomes.
In patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with a different clinical outcome 1 year after neurosurgery.
NCT02360683.
This study provides Class II evidence that in patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with poorer outcomes 1 year post surgery.
Keywords
Deep Brain Stimulation, Humans, Parkinson Disease/surgery, Parkinson Disease/therapy, Preoperative Period, Prospective Studies, REM Sleep Behavior Disorder/complications, Risk Assessment, Subthalamic Nucleus/physiology, Treatment Outcome
Pubmed
Web of science
Create date
17/04/2025 11:21
Last modification date
18/04/2025 7:05
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