Blood CD9<sup>+</sup> B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation.
Details
Serval ID
serval:BIB_3938D0483818
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blood CD9<sup>+</sup> B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation.
Journal
American journal of transplantation
Working group(s)
COLT and SysCLAD Consortia
Contributor(s)
Jougon J., Velly J.F., Rozé H., Blanchard E., Antoine M., Cappello M., Ruiz M., Sokolow Y., Vanden Eynden F., Van Nooten G., Barvais L., Berré J., Brimioulle S., De Backer D., Créteur J., Engelman E., Huybrechts I., Ickx B., Preiser TJC, Tuna T., Van Obberghe L., Vancutsem N., Vincent J.L., De Vuyst P., Etienne I., Féry F., Jacobs F., Knoop C., Vachiéry J.L., Van den Borne P., Wellemans I., Amand G., Collignon L., Giroux M., Angelescu D., Chavanon O., Hacini R., Martin C., Pirvu A., Porcu P., Albaladejo P., Allègre C., Bataillard A., Bedague D., Briot E., Casez-Brasseur M., Colas D., Dessertaine G., Francony G., Hebrard A., Marino M.R., Protar D., Rehm D., Robin S., Rossi-Blancher M., Augier C., Bedouch P., Boignard A., Bouvaist H., Briault A., Camara B., Chanoine S., Dubuc M., Quétant S., Maurizi J., Pavèse P., Pison C., Saint-Raymond C., Wion N., Chérion C., Grima R., Jegaden O., Maury J.M., Tronc F., Flamens C., Paulus S., Philit F., Senechal A., Glérant J.C., Turquier S., Gamondes D., Chalabresse L., Thivolet-Bejui F., Barnel C., Dubois C., Tiberghien A., Pimpec-Barthes F., Bel A., Mordant P., Achouh P., Boussaud V., Méléard D., Bricourt M.O., Cholley B., Pezella V., Brioude G., D'Journo X.B., Doddoli C., Thomas P., Trousse D., Dizier S., Leone M., Papazian L., Bregeon F., Coltey B., Dufeu N., Dutau H., Garcia S., Gaubert J.Y., Gomez C., Laroumagne S., Mouton G., Nieves A., Picard C., Rolain J.M., Sampol E., Secq V., Perigaud C., Roussel J.C., Senage T., Mugniot A., Danner I., Haloun A., Abbes S., Bry C., Blanc F.X., Lepoivre T., Botturi-Cavaillès K., Loy J., Bernard M., Godard E., Royer P.J., Henrio K., Dartevelle P., Fabre D., Fadel E., Mercier O., Stephan F., Viard P., Cerrina J., Dorfmuller P., Feuillet S., Ghigna M., Hervén P., Le Roy Ladurie F., Le Pavec J., Thomas de Montpreville V., Lamrani L., Castier Y., Mordant P., Cerceau P., Augustin P., Jean-Baptiste S., Boudinet S., Montravers P., Dauriat G., Jébrak G., Mal H., Marceau A., Métivier A.C., Thabut G., Lhuillier E., Dupin C., Bunel V., Falcoz P., Massard G., Santelmo N., Ajob G., Collange O., Helms O., Hentz J., Roche A., Bakouboula B., Degot T., Dory A., Hirschi S., Ohlmann-Caillard S., Kessler L., Schuller A., Bennedif K., Vargas S., Bonnette P., Chapelier A., Puyo P., Sage E., Bresson J., Caille V., Cerf C., Devaquet J., Dumans-Nizard V., Felten M.L., Fischler M., Si Larbi A.G., Leguen M., Ley L., Liu N., Trebbia G., De Miranda S., Douvry B., Gonin F., Grenet D., Hamid A.M., Neveu H., Parquin F., Picard C., Stern M., Bouillioud F., Cahen P., Colombat M., Dautricourt C., Delahousse M., D'Urso B., Gravisse J., Guth A., Hillaire S., Honderlick P., Lequintrec M., Longchampt E., Mellot F., Scherrer A., Temagoult L., Tricot L., Vasse M., Veyrie C., Zemoura L., Dahan M., Murris M., Benahoua H., Berjaud J., Le Borgne Krams A., Crognier L., Brouchet L., Mathe O., Didier A., Krueger T., Ris H.B., Gonzalez M., Aubert J.D., Nicod L.P., Marsland B.J., Berutto T.C., Rochat T., Soccal P., Jolliet P., Koutsokera A., Marcucci C., Manuel O., Bernasconi E., Chollet M., Gronchi F., Courbon C., Hillinger S., Inci I., Kestenholz P., Weder W., Schuepbach R., Zalunardo M., Benden C., Buergi U., Huber L.C., Isenring B., Schuurmans M.M., Gaspert A., Holzmann D., Müller N., Schmid C., Vrugt B., Rechsteiner T., Fritz A., Maier D., Deplanche K., Koubi D., Ernst F., Paprotka T., Schmitt M., Wahl B., Boissel J.P., Olivera-Botello G., Trocmé C., Toussaint B., Bourgoin-Voillard S., Séve M., Benmerad M., Siroux V., Slama R., Auffray C., Charron D., Lefaudeux D., Pellet J.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
19
Number
11
Pages
3162-3175
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24 <sup>hi</sup> CD38 <sup>hi</sup> transitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24 <sup>hi</sup> CD38 <sup>hi</sup> transitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9 <sup>+</sup> B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24 <sup>hi</sup> CD38 <sup>hi</sup> transitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome-free survival.
Keywords
B cell biology, basic (laboratory) research/science, biomarker, bronchiolitis obliterans (BOS), lung transplantation/pulmonology, translational research/science
Pubmed
Web of science
Create date
19/07/2019 19:58
Last modification date
22/10/2020 6:23
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