Lactate release from astrocytes to neurons contributes to cocaine memory formation.

Details

Serval ID
serval:BIB_390181F0C96F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lactate release from astrocytes to neurons contributes to cocaine memory formation.
Journal
BioEssays
Author(s)
Boury-Jamot B., Halfon O., Magistretti P.J., Boutrel B.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
38
Number
12
Pages
1266-1273
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The identification of neural substrates underlying the long lasting debilitating impact of drug cues is critical for developing novel therapeutic tools. Metabolic coupling has long been considered a key mechanism through which astrocytes and neurons actively interact in response of neuronal activity, but recent findings suggested that disrupting metabolic coupling may represent an innovative approach to prevent memory formation, in particular drug-related memories. Here, we review converging evidence illustrating how memory and addiction share neural circuitry and molecular mechanisms implicating lactate-mediated metabolic coupling between astrocytes and neurons. With several aspects of addiction depending on mnemonic processes elicited by drug experience, disrupting lactate transport involved in the formation of a pathological learning, linking the incentive, and motivational effects of drugs with drug-conditioned stimuli represent a promising approach to encourage abstinence.

Pubmed
Create date
11/10/2016 15:21
Last modification date
20/08/2019 13:28
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