SMC complexes sweeping through the chromosome: going with the flow and against the tide.

Details

Serval ID
serval:BIB_38E4210F8957
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
SMC complexes sweeping through the chromosome: going with the flow and against the tide.
Journal
Current opinion in microbiology
Author(s)
Gruber S.
ISSN
1879-0364 (Electronic)
ISSN-L
1369-5274
Publication state
Published
Issued date
04/2018
Peer-reviewed
Oui
Volume
42
Pages
96-103
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Bacteria transcribe, duplicate and segregate their genomes all at once. Conflicts between DNA replication and active transcription are a major source of DNA damage and jeopardize genome integrity and cell survival. Co-orientation of replication forks and transcription units is thought to reduce the impact of such conflicts. Like transcription and replication, chromosome segregation relies on the translocation of multi-subunit protein complexes along DNA. Here, I highlight recent advances in our understanding of two major classes of structural maintenance of chromosomes (SMC) complexes in bacteria: Smc-ScpAB, whose DNA translocation is co-oriented with DNA replication by specific start sites, and MukBEF, which apparently lacks such co-ordination. Potential advantages of centralized and decentralized approaches to chromosome organization are discussed.
Keywords
Bacterial Proteins/genetics, Bacterial Proteins/metabolism, Cell Cycle Proteins/genetics, Cell Cycle Proteins/metabolism, Chromosome Segregation, Chromosomes, Bacterial/genetics, Chromosomes, Bacterial/metabolism, DNA Replication/genetics, DNA, Bacterial/genetics, Multiprotein Complexes/genetics, Multiprotein Complexes/metabolism
Pubmed
Web of science
Create date
30/11/2017 19:04
Last modification date
20/08/2019 14:28
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