Development of a personal dual-phase air sampling method for phthalate diesters

Details

Serval ID
serval:BIB_38CCA2827262
Type
Article: article from journal or magazin.
Collection
Publications
Title
Development of a personal dual-phase air sampling method for phthalate diesters
Journal
Journal of Environmental Monitoring
Author(s)
Hines C.J., Yau A.Y., Zuniga M.M., Wells J.R., Nilsen Hopf Nancy B., Camann D.E.
ISSN
1464-0333 (Electronic)
ISSN-L
1464-0325
Publication state
Published
Issued date
02/2010
Peer-reviewed
Oui
Volume
12
Number
2
Pages
491-499
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Phthalates are used as plasticizers in many industrial and consumer products. Urinary biomonitoring has shown widespread human exposure to phthalates, with workers having especially high exposures. Phthalates can be present in workplace air as either aerosols or vapors depending on source materials, vapor pressure, and processing temperatures. We sought to develop a dual-phase air sampling method for 6 phthalates, dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BzBP), di(2-ethylhexyl) phthalate (DEHP), and di-n-octyl phthalate (DnOP), adaptable to aerosol inlets with known particle collection characteristics. Collection media consisted of a quartz fiber filter and XAD-2 resin. Limit of detection (LOD) and limit of quantification (LOQ) were determined for each phthalate. Phthalate recoveries were evaluated at 3x, 10x and 30x the LOQ, and after storage at -21 degrees C and 21 degrees C. Media were Soxhlet extracted in 10% diethyl ether in hexanes along with an extraction surrogate, di-n-pentyl phthalate-d(4). Gas chromatography/mass spectrometry was performed to quantify the phthalate diesters using di(2-ethylhexyl) phthalate-d(4) as an internal standard. Estimated LODs were 1 microg per sample (BzBP, DEHP, and DnOP), 2 microg per sample (DMP and DBP), and 5 microg per sample (DEP). Mean recoveries under static conditions were 85-104% for DBP, BzBP, DEHP, and DnOP; but <70% for DMP and DEP at 3x and 10x the LOQ. After air was pulled through spiked samples, DMP and DEP recoveries improved to 74-81%. After storage for 62 days, phthalate recovery was better at -21 degrees C than at 21 degrees C. Method accuracy was best for DBP, BzBP, DEHP, and DnOP (range 11-18%), and less so for DMP (28%) and DEP (29%).

Keywords
Air Pollutants, Occupational/analysis, Environmental Medicine/instrumentation, Gas Chromatography-Mass Spectrometry, Humans, Limit of Detection, Linear Models, Occupational Exposure, Phthalic Acids/analysis
Pubmed
Web of science
Create date
30/11/2011 9:49
Last modification date
20/08/2019 13:28
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