Retrovirus-host interactions. The mouse mammary tumor virus model.

Details

Serval ID
serval:BIB_38CB33FA42B7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Retrovirus-host interactions. The mouse mammary tumor virus model.
Journal
Medicina
Author(s)
Acha-Orbea H.
ISSN
0025-7680 (Print)
ISSN-L
0025-7680
Publication state
Published
Issued date
1997
Volume
57
Number
Suppl 2
Pages
43-52
Language
english
Abstract
Mouse mammary tumor virus (MMTV) is a retrovirus which can induce mammary carcinomas in mice late in life by activation of proto-oncogenes after integration in their vicinity. Surprisingly, it requires a functional immune system to achieve efficient infection of the mammary gland. This requirement became clear when it was discovered that it has developed strategies to exploit the immune response. Instead of escaping immune detection, it induces a vigorous polyclonal T-B interaction which is required to induce a chronic infection. This is achieved by activating and then infecting antigen presenting cells (B cells), expressing a superantigen on their cell surface and triggering unlimited help by the large number of superantigen-specific T cells. The end result of this strong T-B interaction is the proliferation and differentiation of the infected B cells leading to their long term survival.
Keywords
Animals, B-Lymphocytes/immunology, Female, Mammary Neoplasms, Experimental/immunology, Mammary Tumor Virus, Mouse/immunology, Mice, Proto-Oncogenes/immunology, Retroviridae Infections/immunology, Superantigens/immunology, T-Lymphocytes/immunology, Tumor Virus Infections/immunology, Virus Integration/immunology
Pubmed
Web of science
Create date
24/01/2008 14:48
Last modification date
20/08/2019 13:28
Usage data