Treatment of atopic eyelid disease using topical tacrolimus following corticosteroid discontinuation in a patient with open-angle glaucoma.

Details

Serval ID
serval:BIB_38C8BCEE1884
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Treatment of atopic eyelid disease using topical tacrolimus following corticosteroid discontinuation in a patient with open-angle glaucoma.
Journal
Cornea
Author(s)
Kymionis G.D., Tsilimbaris M.K., Iliaki O.E., Christodoulakis E., Siganos C.S., Pallikaris I.G.
ISSN
0277-3740 (Print)
ISSN-L
0277-3740
Publication state
Published
Issued date
11/2004
Peer-reviewed
Oui
Volume
23
Number
8
Pages
828-830
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To report a case of atopic eyelid disease treatment using topical tacrolimus in a patient with open-angle glaucoma following corticosteroid discontinuation.
Interventional case report.
A 59-year-old white man with a history of treated open-angle glaucoma (latanoprost 0.005%) was referred to our department for atopic eyelid disease. The patient had received previous treatment with topical corticosteroid ointments (hydrocortisone acetate 1%/dexamethasone 0.1% ointments) that, even though they were effective in controlling atopic eyelid disease, were complicated by markedly elevated intraocular pressure (IOP) (steroid responder). Topical steroids were discontinued while other treatment modalities (such as eyelid hygiene, artificial tears, topical antihistamine drugs, topical mast cell stabilizers, or topical/oral antibiotics) were proven ineffective.
Topical tacrolimus 0.03% ointment (Protopic; Fujisawa, Dublin, Ireland) was applied to the eyelid skin twice daily. An improvement of eyelid inflammation was observed while eczematous skin lesions and erosions were resolved within 15 days. After 6 months of continued topical tacrolimus treatment, there was no evidence of atopic dermatitis recurrence. During this period IOP remained controlled without any evidence of deregulation.
Treatment of atopic eyelid disease with topical tacrolimus, following corticosteroid discontinuation in a steroid responder patient with open-angle glaucoma, seems to be an effective alternative treatment to corticosteroids without the risk of IOP increase.
Keywords
Administration, Topical, Dermatitis, Atopic/complications, Dermatitis, Atopic/drug therapy, Eyelid Diseases/complications, Eyelid Diseases/drug therapy, Glaucoma, Open-Angle/complications, Glaucoma, Open-Angle/drug therapy, Glucocorticoids/therapeutic use, Humans, Immunosuppressive Agents/therapeutic use, Intraocular Pressure, Male, Middle Aged, Tacrolimus/therapeutic use
Pubmed
Web of science
Create date
02/10/2019 9:16
Last modification date
06/10/2019 5:26
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