A pilot study of IL-1 inhibition by anakinra in acute gout

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Serval ID
serval:BIB_38B1272B2FB7
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
A pilot study of IL-1 inhibition by anakinra in acute gout
Journal
Arthritis Research and Therapy
Author(s)
So  A., De Smedt  T., Revaz  S., Tschopp  J.
ISSN
1478-6362 (Electronic)
Publication state
Published
Issued date
2007
Volume
9
Number
2
Pages
R28
Notes
Case Reports Clinical Trial Journal Article
Abstract
Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout. The effectiveness of IL-1 inhibition was first evaluated in a mouse model of monosodium urate crystal-induced inflammation. IL-1 inhibition prevented peritoneal neutrophil accumulation but TNF blockade had no effect. Based on these findings, we performed a pilot, open-labeled study (trial registration number ISRCTN10862635) in 10 patients with gout who could not tolerate or had failed standard antiinflammatory therapies. All patients received 100 mg anakinra daily for 3 days. All 10 patients with acute gout responded rapidly to anakinra. No adverse effects were observed. IL-1 blockade appears to be an effective therapy for acute gouty arthritis. The clinical findings need to be confirmed in a controlled study.
Keywords
Adult Aged Animals Arthritis, Gouty/*drug therapy Chemotaxis, Leukocyte/drug effects Female Humans Interleukin 1 Receptor Antagonist Protein/*therapeutic use Interleukin-1/*metabolism Male Mice Middle Aged Peritonitis/chemically induced/drug therapy Pilot Projects Uric Acid/toxicity
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:18
Last modification date
20/08/2019 13:28
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