High Number of Potential Transmitters Revealed in a Population-based Systematic Hepatitis C Virus RNA Screening Among Human Immunodeficiency Virus-infected Men Who Have Sex With Men.

Details

Serval ID
serval:BIB_38A772ECD7D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High Number of Potential Transmitters Revealed in a Population-based Systematic Hepatitis C Virus RNA Screening Among Human Immunodeficiency Virus-infected Men Who Have Sex With Men.
Journal
Clinical infectious diseases
Author(s)
Braun D.L., Hampel B., Martin E., Kouyos R., Kusejko K., Grube C., Flepp M., Stöckle M., Conen A., Béguelin C., Schmid P., Delaloye J., Rougemont M., Bernasconi E., Rauch A., Günthard H.F., Böni J., Fehr J.S.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Anagnostopoulos A., Battegay M., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fellay J., Furrer H., Fux C.A., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kovari H., Ledergerber B., Martinetti G., de Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Rudin C., Scherrer A.U., Speck R., Tarr P., Trkola A., Vernazza P., Wandeler G., Weber R., Yerly S.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Publication state
Published
Issued date
01/02/2019
Peer-reviewed
Oui
Volume
68
Number
4
Pages
561-568
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The proportion of undiagnosed hepatitis C virus (HCV) infections in high-risk populations, such as human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) is unclear. Identification of potential HCV transmitters is important to reach World Health Organization HCV elimination targets.
Between October 2015 and May 2016, we performed a systematic HCV RNA-based screening among HIV-infected MSM participating in the Swiss HIV Cohort Study (SHCS). HCV antibodies were measured from all HCV RNA-positive samples.
Of 4257 MSM recorded in the SHCS database, we screened 3722 (87%) by HCV polymerase chain reaction, and 177 (4.8%) harbored a replicating HCV infection. We identified 24 individuals (14%) with incident HCV infection; one-third of them had a negative HCV antibody result at the time of HCV RNA positivity. In a multivariable model, elevated liver enzyme values (odds ratio, 14.52; 95% confidence interval, 9.92-21.26), unprotected sex with occasional partners (2.01; 1.36-2.98), intravenous drug use (7.13; 4.36-11.64), noninjectable drug use (1.94; 1.3-2.88), and previous syphilis diagnosis (2.56; 1.74-3.76) were associated with HCV RNA positivity.
A systematic HCV RNA-based screening among HIV-infected MSM revealed a high number of potential transmitters. A substantial subpopulation of MSM had incident infection, one-third of whom had a negative HCV antibody test result at the time of the HCV RNA positivity. These data reveal that one-time RNA testing of a high-risk population for HCV RNA might identify more infected persons than routine testing for HCV antibodies and liver enzymes.
NCT02785666.
Keywords
Adult, Disease Transmission, Infectious, HIV Infections/complications, Hepacivirus/genetics, Hepacivirus/isolation & purification, Hepatitis C/complications, Hepatitis C/diagnosis, Hepatitis C/epidemiology, Hepatitis C/transmission, Homosexuality, Male, Humans, Incidence, Male, Middle Aged, Molecular Diagnostic Techniques, Prospective Studies, RNA, Viral/genetics, RNA, Viral/isolation & purification
Pubmed
Web of science
Open Access
Yes
Create date
20/08/2018 12:41
Last modification date
05/04/2020 5:20
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